Download Adhesion Molecules: Function and Inhibition by Klaus Ley PDF

By Klaus Ley

Inflammatory phone recruitment calls for the concerted motion of no less than 5 significant units of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate buildings serving as selectin ligands, and likely ectoenzymes. This quantity supplies a accomplished assessment at the such a lot proper leukocyte and endothelial adhesion molecules. The chapters are written through leaders within the box and concentrate on the biology, constitution, functionality, and law of adhesion molecules. presently authorized adhesion molecule-based cures are reviewed and an outlook for destiny techniques is usually provided.

The publication is of curiosity to clinicians and scientists from immunology, body structure, melanoma learn, rheumatology, allergology, infectious ailments, gastroenterology, pulmonology and cardiology.

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Extra info for Adhesion Molecules: Function and Inhibition

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This Lselectin-induced adhesion required energy metabolism, an intact cytoskeleton, and kinase function. Importantly, the binding of many other L-selectin mAbs to regions of the molecule other than the lectin domain did not trigger activation. In addition, activation of L-selectin through GlyCAM-1 binding results in increased integrinmediated adhesion [8, 140]. Taken together, these findings suggest an important role for L-selectin-induced activation of leukocyte integrins in regulating adhesive interactions with the vascular endothelium (Fig.

Taken together, these findings suggest an important role for L-selectin-induced activation of leukocyte integrins in regulating adhesive interactions with the vascular endothelium (Fig. 2). Other reports suggest a role for L-selectin-mediated signaling in influencing leukocyte chemotaxis. Specifically, in addition to reductions in numbers of leukocytes recruited in an antigen challenge model, leukocytes in L-selectin-deficient mice migrated a shorter distance away from the vessel wall than did wild-type cells [141].

Specific isoforms of PKC responsible for phosphorylation of L-selectin have now been identified [146]. Although the mechanism by which phosphorylation of L-selectin could influence ligand-binding activity is unknown, indirect evidence suggests that dimerization of the receptor may be involved. Specifically, enforced dimerization of L-selectin using the coumermycin/GyrB system enhances L-selectin-dependent leukocyte adhesion with a marked reduction in leukocyte rolling velocities on endothelial cell monolayers [147].

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