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By John A. Borrelli, Ylenia D. Giannini

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Virology, 2000. 267(1): p. 102-10. [47] Logvinoff, C. L. Epstein, Intracellular Cre-mediated deletion of the unique packaging signal carried by a herpes simplex virus type 1 recombinant and its relationship to the cleavage-packaging process. J Virol, 2000. 74(18): p. 8402-12. , V. L. Epstein, Improved packaging system for generation of high-level noncytotoxic HSV-1 amplicon vectors using Cre-loxP site-specific recombination to delete the packaging signals of defective helper genomes. Hum Gene Ther, 2003.

A. and N. Frenkel, Replication of herpes simplex virus DNA: localization of replication recognition signals within defective virus genomes. Proc Natl Acad Sci U S A, 1981. 78(2): p. 742-6. A. A. Schaffer, Cloning and characterization of herpes simplex virus type 1 oriL: comparison of replication and proteinDNA complex formation by oriL and oriS. J Virol, 1995. 69(3): p. 137788. J. M. Wilkie, Nucleotide sequences of the joint between the L and S segments of herpes simplex virus types 1 and 2. J Gen Virol, 1981.

Melendez, Alejandra I. Aguirre, Maria V. Baez et al. Amplicon Vectors and Behaviour Amplicon vectors have been delivered into distinct brain regions to investigate complex aspects of the normal functioning of the central nervous system (CNS). g. dominant-negative mutants) relevant for CNS functions, like proteins directly involved in neurotransmission and in neuron signaling. A comprehensive review on the use of amplicons vectors to study behaviour can be found in Jerusalinsky and co-workers (2012) [20].

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