Download Angiotensin Protocols (Methods in Molecular Medicine) by Donna H. Wang PDF

By Donna H. Wang

Donna Wang and a panel of hands-on specialists describe in step by step aspect all of the significant molecular, biochemical, and sensible concepts now utilized in probing the renin-angiotensin approach. those diversity from using embryonic gene concentrating on to create of mutant lines, to the practical research of parts of the renin-angiotensin approach. complete and hugely useful, Angiotensin Protocols interprets professional wisdom into without problems reproducible equipment that permit all biomedical investigators effectively to discover the position of angiotensin in healthiness and disorder at the present time.

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The synthesis of the first orally active ACE inhibitor, captopril, by Ondetti, Rubin, and Cushman at Squibb in 1977 was a major therapeutic advance, as well as a model of successful drug design (62). In 1978, researchers at Merck Laboratories synthesized enalapril, the first orally active ACE inhibitor lacking a sulfhydryl group. The ready availability of captopril and enalapril permitted long-term blockade of the studies RAS which, in turn, led to an explosion of experimental and clinical studies and the development of many new ACE inhibitors.

Borkowski, A. , and Laragh, J. H. (1965) Prolonged infusions of angiotensin II and norepinephrine and blood pressure, electrolyte balance, and aldosterone and cortisol secretion in normal man and in cirrhosis with ascites. J. Clin. Invest. 44, 1171–1185. 43. Freeman, R. , Davis, J. , Vitale, S. , and Johnson, J. A. (1973) Intrarenal role of angiotensin II. homeostatic regulation of renal blood flow. Circ. Res. 32, 692–698. 44. Hall, J. , Guyton, A. , Trippodo, N. , Lohmeier, T. , McCaa, R. , and Cowley, A.

Novick, A. , Tarazi, R. , Vidt, D. , and Pohl, M. (1985) Critical perfusion pressure for renal function in patients with bilateral atherosclerotic renal vascular disease. Ann. Intern. Med. 102, 308–314. 21. Tuttle, K. , Chouinard, R. , Webber, J. , Dahlstrom, L. , Short, R. , Henneberry, K. , et al. (1998) Treatment of atherosclerotic ostial renal artery stenosis with the intravascular stent. Am. J. Kidney Dis. 32, 611–622. 22. , Mackenzie, H. , Troy, J. , Rennke, H. , and Brenner, B. M. (1998) Effects of combination therapy with enalapril and losartan on the rate of progression of renal injury in rats with 5/6 renal mass ablation.

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