Download Antiviral Drug Discovery for Emerging Diseases and by Paul F. Torrence PDF

By Paul F. Torrence

Antiviral Drug Discovery provides readers a state-of-the-art view of ways chemical thoughts are being mobilized to strengthen novel techniques that would successfully confront rising illnesses and biowarfare. one of the subject matters mentioned are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. each one bankruptcy discusses hypothetical concepts for the invention of proper antiviral brokers, contemporary findings regarding biochemistry or drug discovery, and advances within the extra improvement of tested leads within the sector. well timed and informative, this booklet sincerely delineates the efforts being made to boost new and potent broad-spectrum antiviral brokers.

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Antiviral Res. 2003, 57, 25–33. 28 VIRAL BIOTERRORISM AND ANTIVIRAL COUNTERMEASURES 31. ; Roy, C. Treatment of aerosolized cowpox virus infection in mice with aerosolized cidofovir. Antiviral Res. 2002, 54, 129–142. 32. ; Bray, M. Aerosolized cidofovir is retained in the respiratory tract and protects mice against intranasal cowpox virus challenge. Antimicrob. Agents Chemother. 2003, 47, 2933–2937. 33. Kern, E. ; Beadle, J. ; Hostetler, K. Y. Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir.

G. ), ASM Press, Washington, DC, 2002, pp. 875–890. 27. Bray, M. Defense against filoviruses used as biological weapons. Antiviral Res. 2003, 57, 53–60. 28. Anonymous. Infection control for viral hemorrhagic fevers in the African health care setting. Centers for Disease Control and Prevention, Atlanta, 1998. 29. Baker, R. ; Huggins, J. W. Potential antiviral therapeutics for smallpox and other orthopoxvirus infections. Antiviral Res. 2003, 57, 13–23. 30. ; De Clercq, E. Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives.

SKH-1 hairless mice (immunocompetent or immunosuppressed) readily became infected with either vaccinia or cowpox when virus was applied to abraded skin. 162,163 Huggins and co-workers reported that cynomolgus monkeys infected with monkeypox either by small-particle aerosol or by intravenous inoculation developed classical poxvirus lesions and pulmonary distress, while one model using intravenous variola produced a similar lesional disease and 33% mortality. CDV prophylaxis was completely protective.

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